Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action
نویسندگان
چکیده
منابع مشابه
Action of brain-derived neurotrophic factor on function and morphology of visual cortical neurons
Brain-derived neurotrophic factor (BDNF) is known to play a role in experience-dependent plasticity of the developing visual cortex. For example, BDNF acutely enhances long-term potentiation and blocks long-term depression in the visual cortex of young rats. Such acute actions of BDNF suggested to be mediated mainly through presynaptic mechanisms. A chronic application of BDNF to the visual cor...
متن کاملAction of brain-derived neurotrophic factor on function and morphology of visual cortical neurons
Brain-derived neurotrophic factor (BDNF) is known to play a role in experience-dependent plasticity of the developing visual cortex. For example, BDNF acutely enhances long-term potentiation and blocks long-term depression in the visual cortex of young rats. Such acute actions of BDNF suggested to be mediated mainly through presynaptic mechanisms. A chronic application of BDNF to the visual cor...
متن کاملBrain-Derived Neurotrophic Factor for Depression Therapeutics
Increasing evidence over the last two decades has indicated that the pathophysiology of Major Depressive Disorder (MDD) and the action of antidepressants both involve Brain-Derived Neurotrophic Factor (BDNF), a major neuronal growth factor in the brain. MDD is a complex disorder that results from genetic and environmental influences, singly or in combination. This article reviews the current kn...
متن کاملBrain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression.
Previous studies demonstrated that antidepressant treatment increases the expression of brain-derived neurotrophic factor (BDNF) in rat hippocampus. The present study was conducted to test the hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms. A single bilateral infusio...
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The anticonvulsant drug lamotrigine has been shown to produce antidepressant effects in patients with bipolar disorder. To date, only a few preclinical studies have been conducted using lamotrigine treatment in the forced swim test (FST), an animal model of depression with low face validity. The underlying mechanisms by which lamotrigine works have not been well characterized either. This study...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2021
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2021.05.008